New Daily Persistent Headache being poorly understood, we hope to bring interest and possibly demonstrate involved pathways of mechanism for future study. We are interested in funding trials of combinations of off label readily available medications that have a history of anecdotal limited efficacy in treating the symptoms of New Daily Persistent headache and or other related symptoms.  For example: neurontin, flunarizine, propranolol, topiramate, famciclovir, LDN have some history of efficacy for NDPH. We are interested in multiple combinations of these drugs which have in other trials shown greater efficacy with a synergistic effect towards a variety of conditions.   66% of chronic migrainers also present with fibromyalgia. We are interested in trialing off label readily available medications that have some efficacy in treating chronic migraine and fibromyalgia. We believe that some patients with chronic migraine, NDPH, fibromyalgia, PTSD, ME/CFS, have more in common with each other than with episodic migrainers.  We are open to the idea that NDPH is not a subset of migraine at all and that perhaps it should be studied along with neuroinflammatory conditions triggered by some metabolic dysfunction.

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