Here we  list articles and papers on various subjects such as: Chronified Headache, ME/CFS, Dysautonomia, Fibromyalgia, POTS, GWI, PTSD, CRPS, EDS, MCS, MCAS, Lyme, Bartonella, Autoimmunity, Pain, Immune Molecules, Inflammation, etc.  These are all poorly understood chronic illnesses. They may possibly share some neuro-inflammatory, pathogenic & genetic pathways to systems involved with NDPH. There is research being done in these fields that may offer relevant information that may help point towards needed research for NDPH.  We believe collaboration is key.


System Reset? Study Suggests Pro-Inflammatory / Autoimmune Reset Occurred in Chronic Fatigue Syndrome (ME/CFS)

By Cort Johnson – Aug 4, 2018


2018 Dysautonomia International Conference Pt. 1: Small Fiber Neuropathy, POTS, MCAS and Vagus Nerve Stimulation

By Cort Johnson – July 18, 2018


The 2018 Dysautonomia Conference Pt. 2: Could You Have a Spinal Fluid Leak? An ME/CFS, POTS, FM Perspective

By Cort Johnson – July 21, 2018


Dysautonomia International Conference Pt 3: The Autoimmunity Revolution in POTS

By Cort Johnson  – July 27, 2018


The Cortene Way: New Drug to Be Trialed in Chronic Fatigue Syndrome (ME/CFS) – pt.1

By Cort Johnson – Feb 8, 2018


Cortene 2: A New Drug & A New Hypothesis For Chronic Fatigue Syndrome (ME/CFS)

By Cort Johnson – Feb 17, 2018


Cortene – A New Drug for Chronic Fatigue Syndrome (ME/CFS) Pt. 3: The Clinical Trial

By Cort Johnson – Mar 16, 2018


The Cortene Chronic Fatigue Syndrome (ME/CFS) Drug Trial Begins

By Cort Johnson – July 14, 2018


Through the Looking Glass: Cerebral Spinal Fluid Leaks & Ehlers Danlos Syndrome – an Alternate Reality to ME/CFS?

By Caroline Christian – Dec 1, 2017


One Gene, Many Disorders: Could One Gene Help Explain ME / CFS, FM. POTS, IBS, EDS, IBS and Others

By Cort Johnson – Nov 6, 2016


The Autoimmune Virus? Groundbreaking EBV Finding Could Help Explain ME/CFS

By Cort Johnson – Apr 30, 2018



By Nancy Klimas, M.D.


Quercetin Reduces Pain, Anxiety, and Depression

By Byron J. Richards


Palmitoylethanolamide for the treatment of pain: pharmacokinetics, safety and efficacy

By Linda Gabrielsson – May 24, 2016


Therapeutic utility of palmitoylethanolamide in the treatment of neuropathic pain associated with various pathological conditions: a case series

By Jan M Keppel Hesselink – Oct 26, 2016


PACAP and its role in primary headaches

By Lars Edvinsson – Mar 9, 2018


PACAP38: Emerging Drug Target in Migraine and Cluster Headache

By Anne Luise Haulund Vollesen, MD – May 9, 2017


The importance of lactic acid in migraines and fibromyalgia

By Guido Assis Cachuba de Sá Ribeiro – Sep 8, 2015


Brain discovery may lead to new treatments for peripheral neuropathy

By Catharine Paddock, PhD – Oct 12, 2015


Ketogenic Diets and Pain

By Susan A. Masino, Ph.D. – May 16, 2013


Benign Joint Hypermobility Minimally Impacts Autonomic Abnormalities in Pediatric Subjects with Chronic Functional Pain Disorders

By Gisela Chelimsky – Oct. 2016


Gastrointestinal manifestations of pediatric autonomic disorders

By Gisela Chelimsky – Mar. 2013


Cyclooxygenase-1 and -2 Are Required for Production of Infectious Pseudorabies Virus

By Neelanjana Ray – Jul. 23, 2004


Quercetin Suppresses Cyclooxygenase-2 Expression and Angiogenesis through Inactivation of P300 Signaling

By Xiangsheng Xiao – Aug. 8, 2011


Synthetic and naturally occurring COX-2 inhibitors suppress proliferation in a human oesophageal adenocarcinoma cell line (OE33) by inducing apoptosis and cell cycle arrest

By E. Cheong – Oct 1, 2004


Combination therapy boosts antiviral response to chronic infection

By Ziba Kashef – Mar 23, 2015


Migraine Headache Treated with Famciclovir and Celecoxib: A Case Report

By Bradford Lee NaPier, MD – Nov 29, 2017


Celecoxib activates a novel mitochondrial apoptosis signaling pathway

By Verena Jendrossek – Jun 17, 2003


Celecoxib Enhances the Efficacy of Low-Dose Antibiotic Treatment against Polymicrobial Sepsis in Mice and Clinical Isolates of ESKAPE Pathogens

By Madhavi Annamanedi – May 8, 2017


IVIg for apparently autoimmune small-fiber polyneuropathy: first analysis of efficacy and safety

By Xiaolei Liu – Jan 8, 2018


The newly discovered lymphatic system in the brain, and a possible microbiome

By Amy Proal – Nov 11, 2015


Bartonella sp. Bacteremia in Patients with Neurological and Neurocognitive Dysfunction

By E. B. Breitschwerdt – Jul 16, 2008


Bartonella spp. Bacteremia and Rheumatic Symptoms in Patients from Lyme Disease-endemic Region

By Ricardo G. Maggi – May 2012


Co-infection with Anaplasma platys, Bartonella henselae and Candidatus Mycoplasma haematoparvum in a veterinarian

By Ricardo G. Maggi – Apr 15, 2013


Detection of Bartonella Species in the Blood of Veterinarians and Veterinary Technicians: A Newly Recognized Occupational Hazard?

By Paul M. Lantos – Aug 1, 2014


Neurological Manifestations of Bartonellosis in Immunocompetent Patients: A Composite of Reports from 2005-2012

By E. B. Breitschwerdt – Nov 4, 2012


Bartonellosis, One Health and all creatures great and small

By Edward B. Breitschwerdt – Jan 29, 2017


KPAX002 as a treatment for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): a prospective, randomized trial

By Jose G. Montoya – Mar 15, 2018


Micronutrient Supplementation Increases CD4 Count in HIV-Infected Individuals on Highly Active Antiretroviral Therapy: A Prospective, Double Blinded, Placebo-Controlled Trial

By Jon D. Kaiser, MD – Aug 15, 2006


Inhibition of Peripheral TNF-a and Downregulation of Microglial Activation by Alpha-Lipoic Acid and Etanercept Protect Rat Brain Against Ischemic Stroke.

By Wu MH – Sep 15, 2015


Biochemical and clinical relevance of alpha lipoic acid: antioxidant and anti-inflammatory activity, molecular pathways and therapeutic potential.

By Tibullo D – Jul 4, 2017


Ten Powerful & Safe Anti-Inflammatory Supplements

By Poliquin Group Editorial Staff – Oct 4, 2017


Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson’s disease

By Souvarish Sarkar – Oct 17, 2017


The inflammasome as a target for pain therapy

By H. Zhang – Dec 12, 2016


Stress-Induced Infectious Diseases

By Ingrid Koo, PhD – Apr 24, 2018


Phospholipid profiling of plasma from GW veterans and rodent models to identify potential biomarkers of Gulf War Illness

By Tanja Emmerich – Apr 28, 2017


Tracking post-infectious fatigue in clinic using routine Lab tests

By Jeanna M. Harvey – Apr 26, 2016


Protection of flunarizine on cerebral mitochondria injury induced by cortical spreading depression under hypoxic conditions

By Fengpeng Li – Feb 25, 2011


Mitochondrial behaviour throughout the lytic cycle of Toxoplasma gondii

By Jana Ovciarikova – Feb 16, 2017


Lyme Disease Presenting With Persistent Headache

By James M. Moses, MD – Dec. 2003


Antimicrobial activity of frankincense of Boswellia serrata

By Shaik Mannur Ismail – Oct. 2014


By Wikipedia


New face of an old drug: Celecoxib as an antibacterial agent

By Arunasree M. Kalle – Nov 20-22, 2013


Genetic sleuths solve a medical mystery in breakthrough study

By Daphne Chen – Mar 16, 2016


Genetic Diagnosis Using Whole Exome Sequencing in Common Variable Immunodeficiency

By Patrick Maffucci – Jun 13, 2016


Common variable immunodeficiency following Epstein-Barr virus infection.

By G. Zuccaro


Stem Cell Transplantation For Patients With Common Variable Immunodeficiency- A Retrospective World- Wide Study Of The Current Experience

By American Academy of Allergy Asthma & Immunology – Jan 14, 2015


TACI is mutant in common variable immunodeficiency and IgA deficiency

By Emanuela Castigli – Jul 10, 2005


Selective IgM Deficiency- An Underestimated Primary Immunodeficiency

By Sudhir Gupta – Sep 5, 2017


Depressed serum Igm levels in SLE are restricted to defined subgroups

By  C. Grönwall – Sep 15, 2017


Natural IgM in Immune Equilibrium and Harnessing Their Therapeutic Potential

By Srini V. Kaveri – Feb 1, 2012


How I treat common variable immune deficiency

By Charlotte Cunningham-Rundles – Mar 23, 2010


Antibody deficiencies

By Natural Standard Research Collaboration


Common variable immune deficiency


Testing positive for  beta-2 adrenergic and muscarinic-2 antibodies leads a patient to:

An IVIG Chronic Fatigue Syndrome (ME/CFS) / POTS Treatment Success Story

(The real  news is the drug BC007 by Berlin Cures targeting these antibodies)


“The Subset Maker”: Lipkin Chronic Fatigue Syndrome Study Highlights Energy Issues In Gut Subset

By Cort Johnson – Jul 31, 2018


A reboot for chronic fatigue syndrome research

By Amy Maxmen – Jan 3, 2018


Stanford Team Announces Update On ME/CFS Research

By Adriane Tillman – Feb 22, 2017


Stanford: Scientist searches for answer to his son’s devastating condition

By Lisa M. Krieger – Aug 12, 2017


The Chronic Fatigue Syndrome Research Center (CFSRC)


CFIDS/FMS Scientific Overview: Nancy Klimas, M.D. Lecture


NEID Disease? Study Suggests Neuro, Endocrine and Immune Systems Work Together to Produce ME/CFS

By Cort Johnson – Jan 26, 2018


Could the Epstein-Barr Virus – Autoimmunity Hypothesis Help Explain Chronic Fatigue Syndrome?

By Cort Johnson – May 3, 2014

UPDATED: Metabolic Features of Chronic Fatigue Syndrome – Q & A with Robert Naviaux, MD

Sep 9, 2016


Viruses and CFS: Statements by Ron Davis and Bob Naviaux

Sep 9, 2016


Could Chronic Fatigue Syndrome (ME/CFS) Be a Chronic form of Sepsis?

By Cort Johnson – Jan 1, 2018


Hope for an ME/CFS Autoimmune Subset: A German Researcher Steps Forward

By Cort Johnson – April 1, 2018


Dr. Jarred Younger: Cutting Edge Research on CFS, Neuroinflammation, Pain, and Fatigue

Mar 29, 2016


Calcium Channel ION Defects: Research From Australia’s Griffith Uni.

By Sasha Nimmo – Mar 7, 2017


A “Metabolic Trap” for Chronic Fatigue Syndrome (ME/CFS)?

By Cort Johnson – Apr 3, 2018


Q & A: Avindra Nath, MD – Leading NIH study of post-infection chronic fatigue syndrome

By Shannon Firth – Feb 19, 2018


Major Research Group Highlights Inflammation Energy Production Connection In ME/CFS

By Cort Johnson – Jun 30, 2018


Researchers identify biomarkers associated with chronic fatigue syndrome severity

By Bruce Goldman – Jul 31, 2017


The RCCX Hypothesis: Could It Help Explain Chronic Fatigue Syndrome (ME/CFS), Fibromyalgia and other Diseases?

By Remy – Aug 9, 2018


Antipurinergic therapy for autism- An in depth review

By Robert K. Naviaux – Dec 16, 2017


Consider Mold Toxicity as a Cause of Their Illness

By Neil Nathan MD – Oct 17, 2017


Treating Chemical Injury: Step by Step

By Dr.  Ziem


Dr. Pall’s theory of Multiple Chemical Sensitivity disease mechanism confirmed by Roman study of MCS patients

By – July 5, 2010


The Pall Protocol for Treating CFS/ME

By Erica Verrillo – Mar 26, 2013


Multiple Chemical Sensitivity – The End of Controversy

By Dr. Martin Pall – May 18, 2016


Elevated Nitric Oxide/Peroxynitrite Theory of Multiple Chemical Sensitivity: Central Role of N-Methyl-D-Aspartate Receptors in the Sensitivity Mechanism

By Dr. Martin Pall – Sep. 2003


What Do We Know About Multiple Chemical Sensitivity? An Overview of The Research

By Pamela Reed Gibson , PhD. – Jan 12-14, 2007


An Integrative Approach to Environmental Intolerances: Multiple Chemical Sensitivity and Related Illnesses

By Adam Rindfleisch – June 2012


A Comparison of Multiple Chemical Sensitivity with Other Hypersensitivity and a Path to Answers

By Laurie Dennison Busby – Jun 1, 2017


Blood Test to Detect Fibromyalgia Now Available

By Steve Duffy – Mar 15, 2018

New UAB study could radically change fibromyalgia treatment as we know it

By Donna Gregory Burch – April 24, 2017


Multiple Chemical Sensitivity in Fibromyalgia, ME/CFS

By Adrienne Dellwo – Aug 22, 2017



By Joana Lancastre – Jun 12, 2017


Reduced Pro-Inflammatory Cytokines after Eight Weeks of Low-Dose Naltrexone for Fibromyalgia

By Luke Parkitny – Apr 18, 2017


Carnosine treatment for gulf war illness: a randomized controlled trial.

By James N. Baraniuk – Feb 4, 2013


Has this man conquered Gulf War Syndrome?

By Craig Roberts – Feb 27, 2013


Myalgic encephalomyelitis/chronic fatigue syndrome and gulf war illness patients exhibit increased humoral responses to the herpesviruses-encoded dUTPase: Implications in disease pathophysiology.

By P. Halpin – Apr 26, 2017


A Review of Mitochondrial Optic Neuropathies: From Inherited to Acquired Forms

By Yasmine L. Pilz – Dec 28, 2016



By Cristy Balcells – Jul 11, 2008


MELAS with Migraines and Diabetes


Dr. Doug Wallace discusses Mitochondrial Genetics and Disease

By – May 14, 2018


The Mitochondrial Nexus Behind Chronic Illness

Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performance

By Mari-Carmen Gomez-Cabrera – Jan 1, 2008


Exercise-induced mitochondrial dysfunction: a myth or reality?

By SM Ostojic – Aug 1, 2016


ALDH2 restores exhaustive exercise-induced mitochondrial dysfunction in skeletal muscle.

By Q. Zhang – Feb 27, 2017


Oxidative stress measured in vivo without an exogenous contrast agent using QUEST MRI

By Bruce A. Berkowitz – Apr 26, 2018


Gardasil and Bartonella: A Dirty Little Secret?

By Lloyd Phillips – Jun 10, 2013


What the Gardasil Testing May Have Missed

By Frederik Joelving – Dec 17, 2017


Comparison of the effect of topiramate versus gabapentin on neuropathic pain in patients with polyneuropathy: A randomized clinical trial

By Surena Nazarbaghi – Oct 25, 2017


Fibromyalgia, H.IV. and Chronic Fatigue

By The New York Times – Jan 21, 2010


Restoring Cytokine Balance in HIV-Positive Individuals with Low CD4 T Cell Counts

By Anddre Valdivia – May 10, 2017


Treatment with glutathione precursor decreases cytokine activity.

By L.R. Pena – Jan. 1999


The potential role of the antioxidant and detoxification properties of glutathione in autism spectrum disorders: a systematic review and meta-analysis

Penelope AE Main – Apr 24, 2012


A novel combination approach of human polyclonal IVIG and antibiotics against multidrug-resistant Gram-positive bacteria

By Mariam Madkour Sallam – Dec 8, 2016


Treating Chemical Sensitivity

By Dr. Lauren Deville – Mar 25, 2016


Chronic unremitting headache associated with Lyme disease-like illness

By Pedro Andre Kowacs – Mar 19, 2013


Ketogenic diet improves behaviors in a maternal immune activation model of autism spectrum disorder

By David N. Ruskin – Feb 6, 2017


Recommendations for Treatment of Human Infections Caused by Bartonella Species

By J. M. Rolain –  May 21, 2004


Microglia and Beyond: Innate Immune Cells As Regulators of Brain Development and Behavioral Function

By Kathryn M. Lenz – Apr 13, 2018


Primary Immunodeficiency Panel


Cytokine Storm


Altered kynurenine pathway metabolites in serum of chronic migraine patients

By Martina Curto – Apr 29, 2016


Interactions of Tryptophan and Its Catabolites With Melatonin and the Alpha 7 Nicotinic Receptor in Central Nervous System and Psychiatric Disorders: Role of the Aryl Hydrocarbon Receptor and Direct Mitochondria Regulation

By George Anderson – Feb 16, 2017


Metabolic consequences of interleukin-6 challenge in developing neurons and astroglia

By Jacquelyn A. Brown – Nov 6, 2014


Emerging Functions of Natural IgM and Its Fc Receptor FCMR in Immune Homeostasis

By Hongsheng Wang – Mar 15, 2016

Are Chronic Fatigue Syndrome, POTS, and Fibromyalgia Autoimmune Dysautonomias? IVIG #2

By Cort Johnson – Aug 13, 2018


Natural IgM and the Development of B Cell-Mediated Autoimmune Diseases

By Trang T. T. Nguyen – Feb 6, 2017


Protective Roles of Natural IgM Antibodies

By Caroline Gronwall – Apr 4, 2012


Natural IgM immune equilibrium and harnessing their therapeutic potential

By Srini V. Kaveri – Feb 1, 2012